JAK signaling globally counteracts heterochromatic gene silencing
نویسندگان
چکیده
منابع مشابه
Modulation of a Transcription Factor Counteracts Heterochromatic Gene Silencing in Drosophila
Variegation is a common feature of gene silencing phenomena, yet the basis for stochastic on/off expression is unknown. We used a conditional system that allows probing of heterochromatin at a reporter GFP gene by altering GAL4 transcription factor levels during Drosophila eye development. Surprisingly, the frequency of gene silencing is exquisitely sensitive to GAL4 levels, as though binding s...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2006
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1860